| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871688 | FEBS Letters | 2011 | 6 Pages |
Abstract
⺠The role of the metal-ion in the catalytic domain closure of IPMDH has been investigated. ⺠SAXS studies of the Thermus thermophilus enzyme showed no domain closure without the metal. ⺠Only the metal-IPM complex is efficient in stabilizing the native E. coli enzyme conformation. ⺠FRET studies with both IPMDHs confirm the importance of the metal. ⺠A possible atomic level explanation of the metal-effect is given.
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Authors
Ãva Gráczer, Peter V. Konarev, Tamás Szimler, András Bacsó, Adrienn Bodonyi, Dmitri I. Svergun, Péter Závodszky, Mária Vas,