Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10871693 | FEBS Letters | 2011 | 9 Pages |
Abstract
⺠We model the effect of Trx-1 on MMP-9 expression and involvement in breast cancer. ⺠Trx-1 stimulates MMP-9 expression by increasing NF-κB mediated transcription. ⺠Trx-1 de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9-dependent invasion. ⺠Trx-1 effects on MMP-9 are reversed by dominant negative Trx-1 and NF-κB inhibitors. ⺠Trx-1 and NF-κB are targets for reducing MMP-9 involvement in breast cancer.
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Authors
Antonietta R. Farina, Lucia Cappabianca, Giuseppina DeSantis, Natalia Di Ianni, Pierdomenico Ruggeri, Marzia Ragone, Stefania Merolle, Kathryn F. Tonissen, Alberto Gulino, Andrew R. Mackay,