| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871704 | FEBS Letters | 2012 | 6 Pages |
Abstract
⺠M. tuberculosis fumarase complexes with l-malate, meso-tartrate or fumarate. ⺠First reported crystal structure of a fumarase in complex with fumarate. ⺠Substrate binding leads to active site closure, sequestering from solvent. ⺠Experimental evidence suggests His187 and Ser318 as the acid-base catalysts.
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Authors
Ariel E. Mechaly, Ahmed Haouz, Isabelle Miras, Nathalie Barilone, Patrick Weber, William Shepard, Pedro M. Alzari, Marco Bellinzoni,