| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871710 | FEBS Letters | 2012 | 7 Pages |
Abstract
⺠Reduction of CSN5 leads to a down-regulation of the entire CSN complex. ⺠Reduced CSN5 levels lead to a marked reduction in β-catenin levels. ⺠CSN5 reduction leads to a reduced proliferation capacity of CRC cells. ⺠Surprisingly, CSN5 reduction leads to decreased apoptosis rates in CRC cells. ⺠Our study implies a role for CSN5 and the CSN in promoting colorectal cancer.
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Authors
Anke K. Schütz, Thomas Hennes, Sandra Jumpertz, Simone Fuchs, Jürgen Bernhagen,