| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871720 | FEBS Letters | 2011 | 8 Pages |
Abstract
⺠The RNF20-RNF40 heterodimer acts as an E3 ligase in histone H2B monoubiquitylation. ⺠H2B monoubiquitylation at transcribed chromatin selectively regulates gene expression. ⺠In response to DNA damage, RNF20-RNF40 is recruited to damage sites and phosphorylated by ATM. ⺠H2B monoubiquitylation is required for timely repair of DNA double strand breaks. ⺠The DNA damage response temporarily recruits functional modules from other processes.
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Authors
Yosef Shiloh, Efrat Shema, Lilach Moyal, Moshe Oren,