Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10871729 | FEBS Letters | 2011 | 7 Pages |
Abstract
⺠Tolerance to replication-blocking DNA lesions is essential for genome stability. ⺠Damage bypass can be accomplished at replication forks or at daughter-strand gaps. ⺠A major part of damage bypass in eukaryotes is controlled by ubiquitylation of PCNA. ⺠Ubiquitin-dependent translesion synthesis occurs independently of replication forks. ⺠Higher eukaryotes also use fork-associated mechanisms for damage bypass.
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Authors
Helle D. Ulrich,