Article ID Journal Published Year Pages File Type
10871731 FEBS Letters 2011 7 Pages PDF
Abstract
► The Ku70-Ku80 heterodimer (Ku) is a critical component of the NHEJ pathway. ► Ku removal from DNA is an important aspect of pre- and post-repair mechanisms. ► Ku80 can be removed from DNA via its K48-linked poly-ubiquitylation. ► Ubiquitylation, followed by protein unfolding, is emerging as a general mechanism for the release of DNA-bound proteins.
Related Topics
Life Sciences Agricultural and Biological Sciences Plant Science
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