| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871736 | FEBS Letters | 2011 | 6 Pages |
Abstract
⺠DNA double-strand breaks (DSBs) trigger protein recruitment to DSB-flanking chromatin. ⺠Non-proteolytic ubiquitylation plays a key regulatory role in promoting this response. ⺠The RNF8/RNF168 E3 ligase cascade catalyzes DSB-associated chromatin ubiquitylation. ⺠Ubiquitin and SUMO co-regulate the DSB response by poorly understood mechanisms. ⺠Recent findings on how ubiquitin and SUMO orchestrate responses to DSBs are discussed.
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Authors
Simon Bekker-Jensen, Niels Mailand,