Article ID Journal Published Year Pages File Type
10871736 FEBS Letters 2011 6 Pages PDF
Abstract
► DNA double-strand breaks (DSBs) trigger protein recruitment to DSB-flanking chromatin. ► Non-proteolytic ubiquitylation plays a key regulatory role in promoting this response. ► The RNF8/RNF168 E3 ligase cascade catalyzes DSB-associated chromatin ubiquitylation. ► Ubiquitin and SUMO co-regulate the DSB response by poorly understood mechanisms. ► Recent findings on how ubiquitin and SUMO orchestrate responses to DSBs are discussed.
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