Article ID Journal Published Year Pages File Type
10871744 FEBS Letters 2011 7 Pages PDF
Abstract
► Transthyretin aggregates are toxic to neuronal cells. ► EGCG and curcumin inhibit transthyretin aggregation and originate different small non-toxic off-pathway oligomers. ► EGCG and curcumin efficiently disaggregated pre-formed TTR amyloid fibrils. ► EGCG and curcumin might be used as lead compounds to new therapeutic approaches on transthyretin amyloidoses.
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Life Sciences Agricultural and Biological Sciences Plant Science
Preview
Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation
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