| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871749 | FEBS Letters | 2011 | 6 Pages |
Abstract
⺠We observed prolonged OSM-dependent STAT1 and MAPK activation in STAT3 deficient MEFs. ⺠Fos and Egr1 mRNAs induction was likewise prolonged, independent of MAPK activity. ⺠In vivo STAT1 binding to Fos and Egr1 promoters was observed in STAT3â/â MEFs only. ⺠Inhibiting STAT1 phosphorylation abolishes prolonged Fos and Egr1 induction. ⺠Perturbing STAT3:STAT1 balance alters STAT1 transcriptional activities.
Keywords
sis-inducible elementELK1IRF1SREEGR1FBJ osteosarcoma oncogeneSTAT3PDGFSRFTCFMEFOSMEGFFOSMAPKSiEStat1STAToncostatin Mchromatin immunoprecipitationInterferon regulatory factor 1epidermal growth factorTernary complex factorSerum response elementplatelet-derived growth factorserum response factorsignal transducer and activators of transcriptionmouse embryonic fibroblastsSignal transductionearly growth response 1mitogen-activated protein kinaseImmediate-early genesGas
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Authors
Davide Schiavone, Lidia Avalle, Sarah Dewilde, Valeria Poli,