Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10871750 | FEBS Letters | 2011 | 6 Pages |
Abstract
⺠Heparin and heparan sulfate contain a rare 3-O-sulfoglucosamine residue. ⺠3-O-Sulfoglucosamine is critical for anticoagulation and virus recognition. ⺠The glycosidic linkage proximate to this 3-O-sulfoglucosamine is resistant to heparin lyase cleavage. ⺠Protein engineering of heparin lyase II broadened its specificity towards 3-O-sulfoglucosamine containing substrates.
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Authors
Wenjing Zhao, Marie-Line Garron, Bo Yang, Zhongping Xiao, Jeffrey D. Esko, Miroslaw Cygler, Robert J. Linhardt,