Article ID Journal Published Year Pages File Type
10871792 FEBS Letters 2011 8 Pages PDF
Abstract
► Neuroprotective and regenerative treatments may improve long-term outcomes in multiple sclerosis. ► Restricting demyelination and improving repair may reduce axonal transection. ► Pathways promoting oligodendrocyte viability and myelination include gp130 cytokines, neurotrophins, IGFs and RXR signaling. ► Inhibitors of maturation and myelin formation include bone morphogenetic proteins and the canonical Wnt and Notch pathways. ► Although these avenues are promising, no therapies are yet approved that target these areas in multiple sclerosis patients.
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