| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871885 | FEBS Letters | 2011 | 7 Pages |
Abstract
⺠The malaria parasite P. falciparum biosynthesizes vitamin E. ⺠P. falciparum is the first non-photosynthetic organism that biosynthesizes vitamin E. ⺠Usnic acid, an inhibitor of hydroxyphenylpyruvate dioxygenase, inhibits the plasmodial biosynthesis of vitamin E. ⺠In vitro cultured parasites are inhibited by usnic acid and this is reverted by exogenous vitamin E. ⺠Vitamin E possibly participates in the prevention of lipoperoxidation in the malaria parasite.
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Authors
Rodrigo A.C. Sussmann, Cláudia B. Angeli, Valnice J. Peres, Emilia A. Kimura, Alejandro M. Katzin,