Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872006 | FEBS Letters | 2009 | 7 Pages |
Abstract
We investigated the effect of a periodontal pathogen, Porphyromonas gingivalis, on human aortic smooth muscle cell (hAOSMC) proliferation as mechanisms of atherosclerosis. Cultured hAOSMCs exposed to the supernatant of plasma incubated with P. gingivalis showed a marked transformation from a contractile to proliferative phenotype, resulting in enhancement of cell growth. DNA microarray analysis revealed a P. gingivalis-dependent upregulation of S100A9 in hAOSMCs. Small interference-RNA for S100A9 dramatically attenuated the effect of P. gingivalis on transformation and proliferation of hAOSMCs. Our data suggested that upregulation of S100A9 mediated by P. gingivalis is an important event in the development of aortic intimal hyperplasia.
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Authors
Hiroaki Inaba, Kazuya Hokamura, Kazuhiko Nakano, Ryota Nomura, Kazufumi Katayama, Atsushi Nakajima, Hideo Yoshioka, Kazuhiro Taniguchi, Yoshinori Kamisaki, Takashi Ooshima, Kazuo Umemura, Ferid Murad, Koichiro Wada, Atsuo Amano,