Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872044 | FEBS Letters | 2010 | 5 Pages |
Abstract
Insulin is a secreted peptide that controls glucose homeostasis in mammals, and insulin biosynthesis is regulated by glucose at many levels. Rodent insulin is encoded by two non-allelic genes. We have identified a novel splice variant of the insulin2 gene in mice that constitutes about 75% of total insulin2 mRNA. The alternate splicing does not alter the ORF but reduces the 5â²UTR by 12 bases. A reporter gene containing the novel short 5â²UTR, is more efficiently expressed in cells, suggesting that alternative splicing of insulin mRNA in mice could result in an additional level of regulation in insulin biosynthesis.
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Authors
Amaresh C. Panda, Shardul D. Kulkarni, Bhavana Muralidharan, Baskar Bakthavachalu, Vasudevan Seshadri,