Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872047 | FEBS Letters | 2010 | 6 Pages |
Abstract
Here, we report Prostaglandin A2 (PGA2) induced binding of HSP70 to a novel site on Ï1 SMAR1 5â² UTR which stabilizes the wild type transcript and leads to subsequent increase in SMAR1 protein levels. SMAR1 mediated cell cycle arrest is perturbed in PGA2-treated cells when HSP70 is knocked-down. Contrarily HSP70, unlike SMAR1, is overexpressed in breast cancers. We demonstrate that this is because of the inability of HSP70 to bind to the Ï17 SMAR1 UTR variant which is the predominant form in breast cancers.
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Authors
Lakshminarasimhan Pavithra, Kadreppa Sreenath, Sandeep Singh, Samit Chattopadhyay,