| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10872064 | FEBS Letters | 2011 | 5 Pages |
Abstract
⺠RNA polymerase I (RNAPI) is one of three universally conserved transcription enzymes of eukaryotes. ⺠Its essential and conserved Rpa43 subunit was previously reported to act in transcript initiation. ⺠Large hydrophilic motifs of Rpa43 interact with subunits acting in RNA elongation (Rpa12, Rpa49). ⺠Rpa43 binds the elongation factor Spt5 and the histone chaperone Spt6 in 2-hybrid assay tests. ⺠Rpa43 may thus have a dual role in transcript initiation and promoter escape.
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Authors
Frédéric Beckouët, Sylvie Mariotte-Labarre, Gérald Peyroche, Yasuhisa Nogi, Pierre Thuriaux,