| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10872065 | FEBS Letters | 2011 | 7 Pages |
Abstract
⺠CKII inhibition induced acetylation of p53 at K382 in HCT116 and HEK293 cells. ⺠This acetylation was suppressed by SIRT1 activation. ⺠CKII interacted with SIRT1 and CKII inhibition reduced SIRT1 activity. ⺠SIRT1 overexpression antagonized CKII inhibition-mediated cellular senescence. ⺠Thus, CKII inhibition stabilizes p53 by downregulating SIRT1 during senescence.
Keywords
HDAC5,6-dichloro-1-β-d-ribofuranosylbenzimidazoleSir2SA-β-galCKIIDRBPMSFSirt1PBSMBPSDSNOxsmall-interfering RNAROSsiRNANADPH oxidasesilent information regulator 2sodium dodecyl sulfateTumor suppressionphenylmethylsulfonyl fluoridePhosphate-buffered salinehistone deacetylasemaltose binding proteinSenescenceReactive oxygen species
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Seok Young Jang, Soo Young Kim, Young-Seuk Bae,