Article ID Journal Published Year Pages File Type
10872075 FEBS Letters 2011 4 Pages PDF
Abstract
► Heparan sulfate (HS) biosynthesis is a complex multi-step process. ► N-Deacetylase-N-sulfotransferase (NDST) converts GlcNHAc to GlcNHSO3- residues. ► NDST is considered as a gateway enzyme because it carries out the first modification. ► We show that O-sulfation does not inhibit NDST and NDST can also catalyze maturation. ► We redefine the dynamic role of NDST in the GAGOSOME.
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