Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872075 | FEBS Letters | 2011 | 4 Pages |
Abstract
⺠Heparan sulfate (HS) biosynthesis is a complex multi-step process. ⺠N-Deacetylase-N-sulfotransferase (NDST) converts GlcNHAc to GlcNHSO3- residues. ⺠NDST is considered as a gateway enzyme because it carries out the first modification. ⺠We show that O-sulfation does not inhibit NDST and NDST can also catalyze maturation. ⺠We redefine the dynamic role of NDST in the GAGOSOME.
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Authors
Karthik Raman, Thao Kim Nu Nguyen, Balagurunathan Kuberan,