| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10872095 | FEBS Letters | 2011 | 7 Pages |
Abstract
⺠c-Cbl can promote ligand-induced ubiquitination and consequent degradation of TrkA. ⺠TrkA ubiquitination and degradation required direct interactions between c-Cbl and phosphorylated TrkA. ⺠c-Cbl can induce downregulation of NGF-TrkA complexes through ubiquitination and degradation of TrkA. ⺠c-Cbl has little effect on the internalization of TrkA.
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Authors
Yuga Takahashi, Noriaki Shimokawa, Saeed Esmaeili-Mahani, Akihito Morita, Hiroko Masuda, Toshiharu Iwasaki, Jun'ichi Tamura, Kaisa Haglund, Noriyuki Koibuchi,