Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells

Article ID	Journal	Published Year	Pages	File Type
10872118	FEBS Letters	2011	7 Pages	PDF

Abstract

âº JAK2 V617F mutant enhanced resistance to cisplatin-induced DNA damage. âº JAK2 V617F mutant significantly induces the expression of Aurka. âº Aurka is critical for resistance to DNA damage in transformed cells by JAK2 V617F mutant.

Keywords

Janus Kinase 2 signal transducers and activators of transcription 5 EpoR MPNs STAT5 JAK2 RT-PCR EPO aurora kinase A Aurora kinase AURKA erythropoietin TAE cisplatin Myeloproliferative neoplasm Myeloproliferative neoplasms Reverse transcriptase-polymerase chain reaction Erythropoietin Receptor