Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872189 | FEBS Letters | 2009 | 6 Pages |
Abstract
Interaction between adipocytes and macrophages contributes to the development of insulin resistance in obese adipose tissues. In this study, we examined whether luteolin, food-derived flavonoid, could suppress the production of inflammatory mediators of the interaction between adipocytes and macrophages. Experiments using a coculture system of adipocytes and macrophages showed that luteolin suppressed the production of inflammatory mediators. In addition, activated macrophages were targets for the suppressive effect of luteolin. Luteolin inhibited the phosphorylation of JNK and suppressed the production of inflammatory mediators in the activated macrophages. The findings indicate that luteolin can inhibit the interaction between adipocytes and macrophages to suppress the production of inflammatory mediators, suggesting that luteolin is a valuable food-derived compound for the treatment of metabolic syndrome.
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Authors
Chieko Ando, Nobuyuki Takahashi, Shizuka Hirai, Kanako Nishimura, Shan Lin, Taku Uemura, Tsuyoshi Goto, Rina Yu, Joji Nakagami, Shigeru Murakami, Teruo Kawada,