Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872236 | FEBS Letters | 2010 | 5 Pages |
Abstract
The study of Pseudomonas aeruginosa-II lectin (PA-IIL) complexes with Man derivatives as a recognition factor has been neglected since its monomer is a very weak ligand. Here, the roles of Man oligomers and complexes in PA-IIL carbohydrate-recognition were studied by both enzyme-linked lectinosorbent and inhibition assays. From the results obtained, it is proposed that high density weak -OH conformation as seen in yeast mannan is also an important PA-IIL recognition factor. This finding provides a peculiar concept of the duality of PA-IIL recognition system for lFucα1â and related complexes and for high density Manα1â complexes present in polymannosylated target macromolecules.
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Authors
Albert M. Wu, Yu-Ping Gong, Chia-Chen Li, Nechama Gilboa-Garber,