Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872267 | FEBS Letters | 2011 | 6 Pages |
Abstract
Although well-studied in the context of neurodegenerative disease, a clear biological function for the synuclein proteins remains elusive. Emerging data indicate a role for synucleins in monoamine neurotransmitter homeostasis. A key regulatory component of monoamine neurotransmission is re-uptake of neurotransmitter by the dopamine transporter, norepinephrine transporter, and serotonin transporter, which are common drug targets in the treatment of depression and other mood disorders. Through interactions with these transporters, the neuronal cytoskeleton, and pre-synaptic scaffolding proteins, α-synuclein, β-synuclein, and γ-synuclein modulate trafficking, expression and function of monoamine transporters at the cell surface, thus playing a central role in regulating monoamine re-uptake.
Keywords
5-HTγ-synucleinSyntaxin 1ASerotonin, 5-hydroxytryptamineVMAT2WKYnorepinephrine transporterdesipramineSNAREα-SynDMIDATNACα-synucleinβ-synucleinmood disorderDepressionDopamine transporterAlzheimer’s diseaseParkinson’s diseaseNETCNSDopamineWistar-Kyoto ratSERTserotonin transportercentral nervous systemAnti-depressantMatWistar ratvesicular monoamine transporter 2norepinephrineWissoluble N-ethylmaleimide-sensitive factor attachment protein receptor
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Adam W. Oaks, Anita Sidhu,