| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10872292 | FEBS Letters | 2009 | 7 Pages |
Abstract
Development of early embryos is regulated by autocrine/paracrine factors. Analyzing the expression of polypeptide ligand-receptor pairs using DNA microarray datasets, we identified transcripts for artemin, a member of the GDNF (glial cell line-derived neurotrophic factor) family, its receptor GFRA3 (GDNF family receptor-alpha 3) and coreceptor RET. Here we report an autocrine/paracrine role of the artemin-GFRA3 signaling system in regulating early embryonic development and apoptosis. Possible involvement of the MAP kinase signaling pathway was also demonstrated. The genome-wide survey of ligand-receptor pairs and early embryo cultures provided a better understanding of autocrine/paracrine embryonic factors important for optimal blastocyst development.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Jing Li, Cynthia Klein, Chenguang Liang, Rami Rauch, Kazuhiro Kawamura, Aaron J.W. Hsueh,