Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872327 | FEBS Letters | 2011 | 6 Pages |
Abstract
RIG-G is a retinoic acid- or interferon-induced gene with potential anti-proliferation function. However, the mechanism underlying ATRA-induced RIG-G induction is not completely understood. Here, we demonstrate that ATRA up-regulates the expression of PU.1, which in turn directly binds to the promoter and increases the expression of RIG-G gene. Luciferase reporter assay and electrophoretic mobility shift assay reveal that PU.1 preferentially binds to one of the two putative binding sites on the RIG-G promoter. Moreover, silencing of PU.1 by shRNA markedly inhibited ATRA- but not IFNα-induced expression of RIG-G. These data provide new insight into the mechanism of ATRA-induced RIG-G expression.
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Authors
Zhi-Min Gu, Chuan-Xu Liu, Shao-Fang Wu, Meng Zhao, Han-Zhang Xu, Wei Liu, Hu-Chen Zhou, Guo-Qiang Chen, Ying-Li Wu,