Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872338 | FEBS Letters | 2011 | 7 Pages |
Abstract
S100A8/A9 promotes NADPH oxidase in HaCaT keratinocytes and subsequently increases NFκB activation, which plays important roles in the balance between epidermal growth and differentiation. S100A8/A9-positive HaCaT cells present with a significantly reduced rate of cell division and greater expression of two keratinocyte differentiation markers, involucrin and filaggrin, than control cells. S100A8/A9 mutants fail to enhance NFκB activation, TNFα-induced IL-8 gene expression and NFκB p65 phosphorylation, and S100A8/A9-positive cells demonstrate better cell survival in forced suspension culture than mutant cells. S100A8/A9 is induced in epithelial cells in response to stress. Therefore, S100A8/A9-mediated growth arrest could have implications for tissue remodeling and repair.
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Authors
Andreas Voss, Günther Bode, Claudia Sopalla, Malgorzata Benedyk, Georg Varga, Markus Böhm, Wolfgang Nacken, Claus Kerkhoff,