Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872446 | FEBS Letters | 2007 | 6 Pages |
Abstract
Somatic angiotensin I-converting enzyme (s-ACE) plays a central role in blood pressure regulation and has been the target of most antihypertensive drugs. A displacement isothermal titration calorimetry method has been used to accurately determine the binding constant of three strong s-ACE inhibitors. Under the experimental conditions studied in this work, the relative potency of the inhibitors was determined to be enalaprilat > lisinopril > captopril. We analyze the thermodynamic behaviour of the binding process using the new structural information provided by the ACE structures, as well as the conformational changes that occur upon binding.
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Authors
Montserrat Andújar-Sánchez, Vicente Jara-Pérez, Ana Cámara-Artigas,