Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872481 | FEBS Letters | 2009 | 9 Pages |
Abstract
The GroEL/GroES chaperonin folding chamber is an encapsulated space of â¼65Â Ã
diameter with a hydrophilic wall, inside of which many cellular proteins reach the native state. The question of whether the cavity wall actively directs folding reactions or is playing a passive role has been open. We review past and recent observations and conclude that the chamber functions as a passive “Anfinsen cage” that prevents folding monomers from multimolecular aggregation.
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Authors
Arthur L. Horwich, Adrian C. Apetri, Wayne A. Fenton,