Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872539 | FEBS Letters | 2008 | 6 Pages |
Abstract
We have investigated the radioprotective efficacy of eckol, a component of brown seaweed Ecklonia cava, against the gamma ray-induced damage in vivo. Our results showed that eckol significantly decreased the mortality of lethally irradiated mice. The mechanisms of eckol's protection were found to include: an improvement in hematopoietic recovery, the repair of damaged DNA in immune cells and an enhancement of their proliferation, which had been severely suppressed by ionizing radiation. Thus, we propose eckol as a candidate for adjuvant therapy to alleviate radiation-induced injuries to cancer patients.
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Authors
Eunjin Park, Gin-nae Ahn, Nam Ho Lee, Jeong Mi Kim, Jin Seok Yun, Jin Won Hyun, You-Jin Jeon, Myung Bok Wie, Young Jae Lee, Jae Woo Park, Youngheun Jee,