Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872557 | FEBS Letters | 2007 | 6 Pages |
Abstract
Breast cancer is the most common cancer in women worldwide. To identify novel amplicons involved in the mammary carcinogenesis, we constructed gene expression maps of chromosomes in 35 human breast cancer cell lines and extracted six candidate amplicons containing highly expressed gene clusters on chromosomes 8, 17, and X. We also confirmed the presence of the identified amplicons in clinical specimens by Southern blot analysis. Highly expressed genes identified in the amplicons will contribute to the characterization of breast cancer phenotypes, thereby providing novel targets for anticancer therapies.
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Authors
Emi Ito, Reiko Honma, Yuka Yanagisawa, Jun-ichi Imai, Sakura Azuma, Tetsunari Oyama, Susumu Ohwada, Tetsu Akiyama, Nobuo Nomura, Jun-ichiro Inoue, Shinya Watanabe, Kentaro Semba,