Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872570 | FEBS Letters | 2007 | 5 Pages |
Abstract
We investigated the participation of HDACs in VPA induced apoptosis in Saccharomyces cerevisiae. VPA (20Â mM) induced apoptosis in several HDAC mutants, including PRD3 and HDA1-disrupted cells and SIR2 over expressing cells, as well as in wild-type cells but not SIR2-disrupted cells. Intracellular reactive oxygen species and neutral lipid content increased markedly in all kinds of HDAC mutant cells tested except for SIR2-disrupted cells. Thus, these results suggest that 20Â mM VPA induces neutral lipid accumulation and apoptosis-like features in S. cerevisiae, and that VPA-induced apoptosis was evaded by deletion of SIR2.
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Authors
Qi Sun, Lifu Bi, XiuLan Su, Kunio Tsurugi, Kazuhiro Mitsui,