| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10872681 | FEBS Letters | 2005 | 6 Pages |
Abstract
Apoptosis of rat cardiomyocytes induced by staurosporine is prevented by a stilbene derivative (DIDS), which is a known blocker of both Cl-/HCO3- exchangers and Clâ channels. To clarify its target, staurosporine-induced activation of caspase-3, DNA laddering and cell death were examined in cultured rat cardiomyocytes. Removal of ambient HCO3-, which minimizes the function of Cl-/HCO3- exchangers, failed to affect the preventive effect of DIDS on apoptosis. A carboxylate analog Clâ channel blocker, which does not block Cl-/HCO3- exchangers, also inhibited apoptotic events. Thus, rescue by DIDS of cardiomyocytes from apoptosis is mediated by blockage of Clâ channels.
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Authors
Shigeru Tanabe, Xiaoming Wang, Nobuyuki Takahashi, Hiromi Uramoto, Yasunobu Okada,