Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872702 | FEBS Letters | 2005 | 8 Pages |
Abstract
Ribosome inactivating proteins (RIPs) are protein toxins that are of plant or microbial origin that inhibit protein synthesis by inactivating ribosomes. Recent studies suggest that RIPs are also capable of inducing cell death by apoptosis. Though many reports are available on cell death induced by RIPs, the mechanism involved is not well studied. Comparison of pathways of apoptosis and cellular events induced by various RIPs suggests a central role played by mitochondria, probably acting as an integrator of cellular stress and cell death. The purpose of this review is to compare the various apoptotic pathways that may be involved and propose a general pathway in RIP-induced cell death.
Keywords
MMPTNFAOPRibosome inactivationPseudomonas exotoxinMitochondrial membrane potential (Δψm)CHXPARPPNAGROSmitochondrial stressApoptosisShiga toxincycloheximidetumor necrosis factorMistletoe lectinProtein synthesis inhibitionRIPRibotoxic stress responseRibosome inactivating proteinPoly(ADP-ribose) polymeraseReactive oxygen species
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Sriram Narayanan, Kalpana Surendranath, Namrata Bora, Avadhesha Surolia, Anjali A. Karande,