Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872961 | FEBS Letters | 2005 | 4 Pages |
Abstract
Tau exon 10 (E10) splicing is a crucial event in its developmental change of tau isoform and tauopathy. To investigate the splicing mechanism, we isolated and compared mouse tau genomic sequence with human sequence. We identified a new element in mouse intron 10 (I10) to suppress E10 splicing, which was located just after the stem-loop region previously proposed in human sequence and found to potentially form another stem-loop. Human I10 with a mutation (+29G to A) causing a decreased E10 splicing was also predicted to form similar double stem-loop, suggesting that this element is universally involved in regulation of E10 splicing.
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Authors
Takenari Yamashita, Takami Tomiyama, Qiang Li, Hideharu Numata, Hiroshi Mori,