Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10872970 | FEBS Letters | 2005 | 6 Pages |
Abstract
Cannabinoid ligands are implicated in many physiological processes and to date two receptors have been identified. However, a growing body of evidence exists that suggests the presence of additional receptors. Whilst cloning the previously described hCB1a, we have identified a novel variant that we call hCB1b. Characterising these two splice variants demonstrates that they have a unique pharmacological profile and that their RNA's are expressed at low levels in a variety of tissues.
Keywords
PEICP55940HU210SR141716PEAGTPγSoleoylethanolamidepalmitoylethanolamide2-AGΔ9-THCGPCR2-arachidonoylglycerol(−)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanolOEAWIN55,212-2Δ9-TetrahydrocannabinolanandamideExpressionsplice variantpolymerase chain reactionPCRpolyethyleneimineCannabinoid
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Authors
Erik Ryberg, Huy Khang Vu, Niklas Larsson, Thierry Groblewski, Stephan Hjorth, Thomas Elebring, Sven Sjögren, Peter J. Greasley,