Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10873312 | FEBS Letters | 2005 | 6 Pages |
Abstract
Axotrophin (axot) is a newly characterised stem cell gene and mice that lack axotrophin are viable and fertile, but show premature neural degeneration and defective development of the corpus callosum. By comparing axot+/+, axot+/â and axotâ/â littermates, we now show that axotrophin is also involved in immune regulation. Both T cell proliferation and T cell-derived leukaemia inhibitory factor (LIF) were suppressed by axotrophin in a gene-dose-dependent manner. Moreover, a role for axotrophin in the feedback regulation of LIF is implicated. This is the first evidence that fate determination mediated by LIF maybe qualified by axotrophin.
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Authors
Su M. Metcalfe, Poorni A. De S. Muthukumarana, H. Lorraine Thompson, Melissa A. Haendel, Gary E. Lyons,