Article ID Journal Published Year Pages File Type
10873401 FEBS Letters 2005 5 Pages PDF
Abstract
We show here that megalin, a member of the low-density lipoprotein receptor family expressed in polarized epithelia, binds NGAL with high affinity, as shown by surface plasmon resonance analysis. Furthermore, a rat yolk sac cell line known to express high levels of megalin, endocytosed NGAL by a mechanism completely blocked by an antibody against megalin.
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Life Sciences Agricultural and Biological Sciences Plant Science
Preview
The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake
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