| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10878637 | Mycoscience | 2005 | 7 Pages |
Abstract
Antimicrobial compounds enokipodins A, B, C, and D were originally isolated from the culture filtrates of Flammulina velutipes mycelial culture. Analysis of antibacterial activity by the paper disk method and quantification of enokipodins A-D by high performance liquid chromatography (HPLC) showed that F. velutipes mycelia produced enokipodins A-D in their late growing phase. Great genetic variability in production of these compounds was observed among ten strains of F. velutipes in analyses of antimicrobial activity by the hole-plate diffusion method and quantification by HPLC. Enokipodins A-D demonstrated antimicrobial activity mainly against the grampositive bacteria Bacillus subtilis and Staphylococcus aureus. Evaluation of minimum inhibitory doses (MIDs) showed that MIDs of enokipodins A and C for B. subtilis were as low as that of the penicillin G antibiotic.
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Authors
Noemia Kazue Ishikawa, Kiyoshi Miura, Satoshi Tahara, Kunihide Takahashi, Keiko Yamaji, Hiroshi Ishimoto, Yukiharu Fukushi, Satoshi Tahara,