| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10891314 | Stem Cell Research | 2013 | 10 Pages |
Abstract
⺠CSF-1R KO eliminates stem and Paneth Cell marker CD24 in the stem cell niche. ⺠The KO defect is cell intrinsic as shown by organoid cultures. ⺠Intestinal-specific CSF-1R KO leads to a progressive elimination of Paneth cells. ⺠This PC loss impacts intestinal stem cell gene expression. ⺠CSF-1R signaling pathway defects may underpin GI disorders.
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Authors
Dilara Akcora, Duy Huynh, Sally Lightowler, Markus Germann, Sylvie Robine, Jan R. de May, Jeffrey W. Pollard, E. Richard Stanley, Jordane Malaterre, Robert G. Ramsay,