Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10891315 | Stem Cell Research | 2013 | 15 Pages |
Abstract
⺠Generation of enriched functional forebrain neurons from human iPS cells ⺠Modeling Alzheimer's disease by demonstration of Aβ toxicity to human iPS neurons ⺠Performing a high-throughput screen for compounds blocking Aβ toxicity ⺠Validation of Cdk2 as a target for blocking Aβ toxic effects
Keywords
CDKterminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labelingCBPsNFTsAPPAβshRNAFACSNPCssmall hairpin RNAβ-AmyloidAlzheimer's diseaseParkinson diseaseTUNELfluorescence-activated cell sortingES cellsiPS cellsInduced pluripotent stem cellsEmbryonic stem cellsNeural progenitor cellsneurofibrillary tanglesretinoblastoma proteinamyloid precursor proteincyclin-dependent kinase
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Authors
Xiaohong Xu, Ying Lei, Jie Luo, Jamie Wang, Shu Zhang, Xiu-Juan Yang, Mu Sun, Emile Nuwaysir, Guohuang Fan, Jing Zhao, Lei Lei, Zhong Zhong,