| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10891333 | Stem Cell Research | 2013 | 9 Pages |
Abstract
⺠Validation of hPSC-CM for predictive cardiac safety pharmacology. ⺠IKs plays an important role in limiting action potential prolongation. ⺠Repolarization reserve determines drug sensitivity. ⺠Diminished repolarization reserve risk factor for QT prolongation and TdP.
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Authors
S.R. Braam, L. Tertoolen, S. Casini, E. Matsa, H.R. Lu, A. Teisman, R. Passier, C. Denning, D.J. Gallacher, R. Towart, C.L. Mummery,