| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10891362 | Stem Cell Research | 2012 | 12 Pages |
Abstract
⺠In vitro maturation of human iPSCs offers an unlimited source of human HLCs. ⺠HLCs perform similar functions, but at a lower level than hepatocytes produced in vivo. ⺠Novel methods are needed to complete differentiation of iPSCs to hepatocytes.
Keywords
CYP2C19HGFCYP3A4HNF4αOct4HLCND5FGF2IPSCNADH dehydrogenase subunit 5BMP4BALqRT-PCRatp8ND1GATA4ALBhiPSCCyPHCFqPCRATP5G1NADH dehydrogenase subunit 1Mitochondrial DNAAlbuminalpha fetoproteinperiodic acid-SchiffTemAFPESCmtDNAHuman induced pluripotent stem cellEmbryonic stem cellInduced pluripotent stem cellhepatocyte-like cellCytochrome P450fibroblast growth factor 2Hepatocyte growth factoroctamer-binding transcription factor 4Transmission electron microscopyPASquantitative reverse transcription polymerase chain reactionquantitative polymerase chain reactionbone morphogenetic protein 4bioartificial liver
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Authors
Yue Yu, Hongling Liu, Yasuhiro Ikeda, Bruce P. Amiot, Piero Rinaldo, Stephen A. Duncan, Scott L. Nyberg,