| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10891364 | Stem Cell Research | 2012 | 10 Pages |
Abstract
⺠Cultured hOPCs were susceptible to IFN-γ-induced apoptosis. ⺠Treatment of hOPCs with IFN-γ induced expression of CXCL10 that also contributed to apoptosis. ⺠Signaling through the chemokine receptor CXCR2 protected hOPCs from either IFN-γ or CXCL10-mediated apoptosis. ⺠ES-derived OPCs are susceptible to inflammatory cytokine/chemokine-mediated apoptosis yet protection is evoked if ligands for CXCR2 are present.
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Authors
Emanuele Tirotta, Leslie A. Kirby, Maya N. Hatch, Thomas E. Lane,