| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10891384 | Stem Cell Research | 2012 | 13 Pages |
Abstract
⺠We characterize the expression and role of Bmi1 in CD133-sorted human GBM. ⺠Bmi1 level is highest during intermediate stages of differentiation in BTICs. ⺠Bmi1 controls self-renewal in CD133+ and differentiation in CD133- cells. ⺠Stem cell assays are predictive of clinical outcome for GBM patients. ⺠Bmi1 in BTIC patient isolates may contribute to current molecular categories of GBM.
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Authors
Chitra Venugopal, Na Li, Xin Wang, Branavan Manoranjan, Cynthia Hawkins, Thorsteinn Gunnarsson, Robert Hollenberg, Paula Klurfan, Naresh Murty, Jacek Kwiecien, Forough Farrokhyar, John P. Provias, Christopher Wynder, Sheila K. Singh,