| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10891386 | Stem Cell Research | 2012 | 11 Pages |
Abstract
⺠Cytogenetic, array and complete genome sequence were used to assess the integrity of human ES cell lines. ⺠FISH methods can detect low level contamination of cultures by genomically aberrant cells. ⺠Copy number variation assessment shows the vast majority of CNVs occur in regions common to normal human genomes. ⺠Complete genome sequence ensures integrity of key gene families (tumor suppressors/oncogenes). ⺠Sequence analysis can identify ABO blood type, HLA and disease-associated alleles.
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Authors
Walter D. Funk, Ivan Labat, Janani Sampathkumar, Pierre-Antoine Gourraud, Jorge R. Oksenberg, Elen Rosler, Daniel Steiger, Nadia Sheibani, Stacy Caillier, Birgit Stache-Crain, Julie A. Johnson, Lorraine Meisner, Markus D. Lacher, Karen B. Chapman,