| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10891391 | Stem Cell Research | 2012 | 11 Pages |
Abstract
⺠Aging increases cell senescence factors like p16ink4a and CHEK1 and affect self-renewal of ASCs. ⺠These are followed by higher expression of DNA repair genes, suggestive of DNA break probabilities. ⺠Subnormal expression of microRNAs involved in cell cycle regulation was observed. ⺠Importantly, differentiation potential of ASCs declined with aging.
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Authors
Eckhard U. Alt, Christiane Senst, Subramanyam N. Murthy, Douglas P. Slakey, Charles L. Dupin, Abigail E. Chaffin, Philip J. Kadowitz, Reza Izadpanah,