Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10891396 | Stem Cell Research | 2012 | 11 Pages |
Abstract
⺠We developed a protocol for generating insulin-producing cells from hiPS cells. ⺠Multiple compounds that induced pancreatic differentiation were identified. ⺠The differentiated cells secreted c-peptide in response to insulin secretagogues. ⺠The differentiated cells expressed various islet-enriched transcription factors. ⺠Five hiPS cell lines showed efficient differentiation into insulin-producing cells.
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Authors
Yuya Kunisada, Noriko Tsubooka-Yamazoe, Masanobu Shoji, Masaki Hosoya,