| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10928299 | Cryobiology | 2011 | 7 Pages |
Abstract
⺠Celgosivir is an effective nanomolar concentration inhibitor against all four dengue virus serotypes. ⺠Celgosivir effectively inhibits DENV-2 in ADE infected THP-1 cells. ⺠NS1 protein misfolds and accumulates in the ER during celgosivir treatment. ⺠Celgosivir treatment promotes the expression of pro-survival ER stress response proteins. ⺠Celgosivir treatment is effective up 48 h post-virus infection in a lethal challenge mouse model.
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Authors
Jeunghwan Choi, John C. Bischof,