Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10972979 | Journal of Comparative Pathology | 2016 | 4 Pages |
Abstract
The aim of this study was to evaluate anaemia, serum iron concentrations and δ-aminolevulinate dehydratase (ALA-D) activity in laying hens infected naturally by Salmonella Gallinarum and having severe hepatic lesions. Liver and serum samples were collected from 27 laying hens (20 infected and seven uninfected). The δ-ALA-D activity, haematocrit and serum iron concentrations were evaluated. There were significant decreases in δ-ALA-D activity, haematocrit and serum iron concentrations (P <0.01) in birds infected by S. Gallinarum when compared with uninfected birds. There was a positive correlation (P <0.001) between serum iron concentration, haematocrit (r2 = 0.82) and δ-ALA-D activity (r2 = 0.75). A positive correlation was also observed between δ-ALA-D activity and haematocrit (r2 = 0.78; P <0.01). Liver samples showed moderate focal coagulative necrosis associated with infiltration of lymphoplasmacytic cells, macrophages and heterophils. The anaemia in the infected hens may be related to reduction in δ-ALA-D activity and serum iron concentrations, since both are important for haemopoiesis.
Keywords
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Authors
A.C. Machado, M.M. Boiago, G.M. do Carmo, N.B. Bottari, D.N. Araujo, J. Giuriatti, V.M. Morsch, M.R.C. Schetinger, R.A. Casagrande, C.S. Wisser, L.M. Stefani, M.S. Alves, A.S. Da Silva,